10/4/2023 0 Comments Venom download the new for apple![]() ![]() This differential affinity of PLA 2s towards phospholipids of different bio-membranes has been used extensively to explore the physical structure of phospholipids in biological membranes. Different isoforms of venom PLA 2 can display dramatically different affinities for bio-membranes, composed of different phospholipids polar head groups and fatty acyl chains, resulting in their differential membrane damaging activity. Studies on such anticoagulant PLA 2s may contribute to understand different “vulnerable” sites in the coagulation cascade which may further help to design novel strategies to develop anticoagulant therapeutics to treat cardiovascular disorder (CVD).įurther, most of the toxic effects of snake venom PLA 2s are exerted by hydrolysis of membrane phospholipids. In addition to enzymatic mechanism of anticoagulant effect, anticoagulant PLA 2 enzymes strongly extend blood coagulation by a mechanism that is independent of phospholipids hydrolysis and is achieved mostly by inhibiting the blood coagulation factor(s). Venom PLA 2s most likely prolong the blood coagulation through hydrolysis of and/or binding to procoagulant phospholipids essential for clotting process. Despite their structural similarities, snake venom PLA 2 enzymes differ greatly in their pharmacological properties and biological activities. ![]() Phospholipase A 2 (PLA 2) is one of the major toxic enzymes present invariably in all snake venoms. ![]() Snake venom plays an important role in incapacitating and immobilizing, as well as in digesting prey after being swallowed. ![]() Snake venom is a complex mixture of pharmacologically active proteins and polypeptides in addition to containing some minor nonprotein components. ![]()
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